KaryoDraw

AML with inv(16)

46,XY,inv(16)(p13q22)

Also known as: CBFB-MYH11, AML M4Eo, inv(16)

46,XY,inv(16)(p13q22) is a pericentric inversion of chromosome 16 that fuses CBFB with MYH11, seen in acute myeloid leukemia with abnormal eosinophils (M4Eo). Like t(8;21), it is a core-binding-factor leukemia with a favorable prognosis.

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inv(16)
16
AML with inv(16) (46,XY,inv(16)(p13q22)) drawn by KaryoDraw, showing the involved chromosomes with their normal homolog.

What the notation means

46
total chromosome count (the normal human number)
XY
sex chromosomes: one X, one Y (usual male karyotype)
inv(16)(p13q22)
an INVERSION in chromosome 16: the segment between 16p13 and 16q22 is flipped end-for-end (pericentric, it spans the centromere)

Related karyotypes

KaryoDraw is a free ISCN 2024 karyotype visualizer, a StudyRare tool. It is an educational visualizer of cytogenetic nomenclature, not a diagnostic tool.