KaryoDraw

AML with t(8;21)

46,XX,t(8;21)(q22;q22)

Also known as: RUNX1-RUNX1T1, AML1-ETO, t(8;21)

46,XX,t(8;21)(q22;q22) is a recurrent translocation in acute myeloid leukemia that fuses RUNX1 with RUNX1T1. It is one of the core-binding-factor leukemias and generally carries a favorable prognosis.

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der(8)
8
der(21)
21
AML with t(8;21) (46,XX,t(8;21)(q22;q22)) drawn by KaryoDraw, showing the involved chromosomes with their normal homolog.

What the notation means

46
total chromosome count (the normal human number)
XX
sex chromosomes: two X (usual female karyotype)
t(8;21)(q22;q22)
a reciprocal TRANSLOCATION: chromosomes 8 and 21 break (at 8q22 and 21q22) and swap the pieces beyond those breaks, giving two derivative chromosomes der(8) and der(21)

Clinical notes

t(8;21), AML

t(8;21)(q22;q22) RUNX1::RUNX1T1; a core-binding-factor AML with generally favorable prognosis.

Related karyotypes

KaryoDraw is a free ISCN 2024 karyotype visualizer, a StudyRare tool. It is an educational visualizer of cytogenetic nomenclature, not a diagnostic tool.