Burkitt lymphoma t(8;14)
46,XX,t(8;14)(q24;q32)
Also known as: MYC-IGH, t(8;14)
46,XX,t(8;14)(q24;q32) is the classic translocation of Burkitt lymphoma. It places the MYC oncogene on chromosome 8 next to the immunoglobulin heavy-chain locus IGH on chromosome 14, driving constant MYC expression.
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What the notation means
46- total chromosome count (the normal human number)
XX- sex chromosomes: two X (usual female karyotype)
t(8;14)(q24;q32)- a reciprocal TRANSLOCATION: chromosomes 8 and 14 break (at 8q24 and 14q32) and swap the pieces beyond those breaks, giving two derivative chromosomes der(8) and der(14)
Clinical notes
t(8;14), Burkitt lymphoma
t(8;14)(q24;q32) places MYC next to the IGH enhancer → MYC overexpression. Classic 'starry-sky' Burkitt lymphoma.