KaryoDraw

Burkitt lymphoma t(8;14)

46,XX,t(8;14)(q24;q32)

Also known as: MYC-IGH, t(8;14)

46,XX,t(8;14)(q24;q32) is the classic translocation of Burkitt lymphoma. It places the MYC oncogene on chromosome 8 next to the immunoglobulin heavy-chain locus IGH on chromosome 14, driving constant MYC expression.

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der(8)
8
der(14)
14
Burkitt lymphoma t(8;14) (46,XX,t(8;14)(q24;q32)) drawn by KaryoDraw, showing the involved chromosomes with their normal homolog.

What the notation means

46
total chromosome count (the normal human number)
XX
sex chromosomes: two X (usual female karyotype)
t(8;14)(q24;q32)
a reciprocal TRANSLOCATION: chromosomes 8 and 14 break (at 8q24 and 14q32) and swap the pieces beyond those breaks, giving two derivative chromosomes der(8) and der(14)

Clinical notes

t(8;14), Burkitt lymphoma

t(8;14)(q24;q32) places MYC next to the IGH enhancer → MYC overexpression. Classic 'starry-sky' Burkitt lymphoma.

Related karyotypes

KaryoDraw is a free ISCN 2024 karyotype visualizer, a StudyRare tool. It is an educational visualizer of cytogenetic nomenclature, not a diagnostic tool.