Mantle cell lymphoma t(11;14)
46,XY,t(11;14)(q13;q32)
Also known as: CCND1-IGH, cyclin D1, t(11;14)
46,XY,t(11;14)(q13;q32) defines mantle cell lymphoma. It brings CCND1 (cyclin D1) next to the immunoglobulin heavy-chain locus IGH, driving cyclin D1 overexpression and cell-cycle progression.
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What the notation means
46- total chromosome count (the normal human number)
XY- sex chromosomes: one X, one Y (usual male karyotype)
t(11;14)(q13;q32)- a reciprocal TRANSLOCATION: chromosomes 11 and 14 break (at 11q13 and 14q32) and swap the pieces beyond those breaks, giving two derivative chromosomes der(11) and der(14)
Clinical notes
t(11;14), Mantle cell lymphoma
t(11;14)(q13;q32) juxtaposes CCND1 (cyclin D1) with the IGH enhancer → cyclin D1 overexpression driving the cell cycle. Defines mantle cell lymphoma.