KaryoDraw

Mantle cell lymphoma t(11;14)

46,XY,t(11;14)(q13;q32)

Also known as: CCND1-IGH, cyclin D1, t(11;14)

46,XY,t(11;14)(q13;q32) defines mantle cell lymphoma. It brings CCND1 (cyclin D1) next to the immunoglobulin heavy-chain locus IGH, driving cyclin D1 overexpression and cell-cycle progression.

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der(11)
11
der(14)
14
Mantle cell lymphoma t(11;14) (46,XY,t(11;14)(q13;q32)) drawn by KaryoDraw, showing the involved chromosomes with their normal homolog.

What the notation means

46
total chromosome count (the normal human number)
XY
sex chromosomes: one X, one Y (usual male karyotype)
t(11;14)(q13;q32)
a reciprocal TRANSLOCATION: chromosomes 11 and 14 break (at 11q13 and 14q32) and swap the pieces beyond those breaks, giving two derivative chromosomes der(11) and der(14)

Related karyotypes

KaryoDraw is a free ISCN 2024 karyotype visualizer, a StudyRare tool. It is an educational visualizer of cytogenetic nomenclature, not a diagnostic tool.