Monosomy 7 (MDS/AML)
45,XX,-7
Also known as: -7, monosomy 7
45,XX,-7 is an acquired monosomy: one whole copy of chromosome 7 is lost in the malignant cells. Monosomy 7 is among the most common cytogenetic abnormalities in myelodysplastic syndrome and acute myeloid leukemia and carries an unfavorable prognosis.
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What the notation means
45- total chromosome count (normal is 46)
XX- sex chromosomes: two X (usual female karyotype)
-7- LOSS of one chromosome 7 (one copy = monosomy 7)